No sting in this tale

Have some nettle tea if you’re suffering from hayfever at the moment – studies have shown it to act to prevent allergic symptoms by multiple mechanisms (Roschek et al., 2009), although its uses don’t stop there by any means. There are generally a lack of studies on nettle leaf, although many on nettle root, which is now commonly used in benign prostatic hyperplasia.

A recent randomized placebo-controlled trial on 50 patients with type 2 diabetes mellitus indicated a significant reduction in measures of damaging oxidative stress (Namazi et al., 2012), at about 5g of nettle leaf per day over 8 weeks. But even if you’re fighting fit, why not take it anyway, as a slightly soup-like alternative to tea? It’s a great tonic and if you wait until the seeds appear, use them as well – they’re reportedly fed to show horses to boost glossiness of coats and pre-clinical studies even show benefit in kidney failure.

 

References

Namazi N, Tarighat A, Bahrami (2012) A The effect of hydroalcoholic nettle (Urtica dioica) extract on oxidative stress in patients with type 2 diabetes: a randomized double-blind clinical trial. Pak J Biol Sci.15;15(2):98-102

Roschek B Jr, Fink RC, McMichael M, Alberte RS. (2009) Nettle extract (Urtica dioica) affects key receptors and enzymes associated with allergic rhinitis. Phytother Res. 23(7):920-6.

Olive leaf in type 2 diabetes and metabolic syndrome

A randomised controlled clinical trial just published in the Journal of Medicinal Food (Wainstien et al., 2012) supports the use of olive leaf in type 2 diabetes.  The study involved 79 patients over 14 weeks and found that measures of glucose in the blood (HbA1c) and fasting insulin levels were significantly reduced, possibly involving a reduction in starch digestion and absorption. The significance of the use of olive leaf to regulate blood glucose is even greater when its use in hypertension and hypercholesterolaemia is considered, as individuals with type 2 diabetes often suffer from these conditions as part of ‘Metabolic Syndrome’ (combined cardiovascular disease and diabetes). OLive leaf has been shown in initial studies to reduce hypertension, possibly via blocking calcium channels (Gilani et al., 2005) and also reduces LDL / VLDL cholesterol (Bennani-Kabchi et al., 2000).

 

References

Bennani-Kabchi N, Fdhil H, Cherrah Y, El Bouayadi F, Kehel L, Marquie G. (2000)  [Therapeutic effect of Olea europea var. oleaster leaves on carbohydrate and lipid metabolism in obese and prediabetic sand rats (Psammomys obesus)]. Ann Pharm Fr. 58(4):271-7.

 

Gilani AH, Khan AU, Shah AJ, Connor J, Jabeen Q. (2005) Blood pressure lowering effect of olive is mediated through calcium channel blockade. Int J Food Sci Nutr. 56(8):613-20.

 

Wainstein J, Ganz T, Boaz M, Bar Dayan Y, Dolev E, Kerem Z, Madar Z. (2012) ‘Olive Leaf Extract as a Hypoglycemic Agent in Both Human Diabetic Subjects and in Rats’. J Med Food. [Epub ahead of print]

ADHD in children and natural approaches

Attention deficit hyperactivity disorder (ADHD) is a group of behavioural symptoms that include inattentiveness, hyperactivity and impulsiveness. Attention deficit disorder (ADD) is a type of ADHD.

Common symptoms of ADHD include:

  • a short attention span
  • restlessness
  • being easily distracted
  • constant fidgeting

Children naturally have a tendency towards the kind of behaviour that ADHD causes, but this behaviour should not be confused with ADHD and a professional diagnosis is vital. ADHD is the most common behavioural disorder in the UK. It is estimated that the condition affects 3–9% of school-aged children and young people

Underlying mechanisms of factors that are associated with ADHD symptoms include:

  • Alterations in dopaminergic and noradrenergic transmission
  • Dysfunction of the reticular activating system
  • Diminished perfusion and cortical activity
  • The right hemisphere of the ADHD brain appears on functional magnetic resonance imaging to be, on average, 5% smaller than that of control groups, including a smaller right anterior frontal cortex and less white matter in the right frontal lobe,  which can impair sustained or focused attention.
  • Children with ADHD exhibit global cortical thinning, predominantly in prefrontal regions, associated with attentional mechanisms
  • Limited essential nutrients – brain maturation in children involves complex, rapid change and growth of nervous tissue and increasing research indicates that this requires adequate external intake of crucial essential nutrients to avoid possible compromise to optimal development. Increasing evidence suggests that these nutritional deficiencies are common in ADHD.

Conventional medication is psychostimulants (e.g. methylphenidate, dexamfetamine) and selective noradrenaline re-uptake inhibitors (e.g. atomoxetine) but these are not without significant side effects and a natural approach including psychological therapies, exercise, herbs and diet may be considered initially.

An herbal and dietary approach broadly aims to enhance cognition, attention, and impulse control via mechanisms such as:

  • Enhancement of catecholaminergic (noradrenaline and dopamine) transmitter functions such as noradrenaline-releasing action
  • Acetylcholinesterase (AChE) inhibitory activity
  • Stimulation of growth of axons and dendrites in human neuroblastoma cells
  • Enhancement of cerebral  oxygenation
  • GABA mimetic activity
  • Provision of essential nutrients
  • Antioxidant effects
  • Supporting healthy digestion, liver function and addressing  possible food intolerance:  e.g. additives, dairy, wheat or gluten, corn, chocolate, caffeine, eggs and citrus fruits may exacerbate symptoms.
  • Addressing possible nutritional deficiencies:  e.g. Iron, zinc, B vitamins, magnesium, essential fatty acids
  • Addressing impaired glucose metabolism:  Avoiding simple sugars and refined carbohydrates will aid glucose and insulin balance
  • Enhancement of sleep if required
  • Reduction of stress and the effects on the body
  • Addressing any allergies such as asthma, eczema, hay fever or migraine

There are many herbs that can be used to address the above issues and a recent 4 month randomised placebo controlled trial (Katz et al., 2010) found that a mix of herbs commonly use in herbal practice was effective in improving symptoms of ADHD in children:

The mix included white paeony (Paeonia alba), ashwaganda (Withania somnifera) , gotu kola (Centella asiatica), Spirulina, Bacopa Monieri and lemon balm (Mellissa officinalis).

  • Paeoniflorin (monoterpene glucoside) isolated from white paeony has demonstrated improved information transfer function of the  cholinergic neuron synapses, seems to increase noradrenaline- releasing action and enhances cerebral oxygenation.
  • Ashwaganda has been found to stimulate growth of axons and dendrites in human neuroblastoma cells, in addition to increasing acetylcholine receptor capacity and AChE inhibitory activity
  • Gotu kola has demonstrated increased neurite elongation, dendritic growth and improved learning and memory. It is especially high in B-vitamins (cofactors in the synthesis and functioning of serotonin, norepinephrine, dopamine, acetylcholine, as well as GABA).
  • Spirulina supplies essential fatty acids, B vitamins, folic acid, vitamin C, vitamin D, and vitamin E, as well as potassium, calcium,  chromium, copper, iron, magnesium, manganese, phosphorus, selenium, and zinc, and all essential amino acids.

Caution: The information here is offered for its educational value only and should not be used to diagnose, treat, or prevent disease; please contact your health care practitioner.

References

Katz M, Levine AA, Kol-Degani H, Kav-Venaki L. (2010) A compound herbal preparation (CHP) in the treatment of children with ADHD: a randomized controlled trial. J Atten Disord. 14(3):281-91.